小島研究室へようこそ
◎論文
1. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T., Tetrahedron Lett., 77, 153249 (2021).
2. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T., Tetrahedron Lett., 61, 151973 (2020).
3. Kishi, N.; Kojima, H., ChemistrySelect, 4, 9570-9572 (2019).
4. Kagawa, N.; Sasaki, Y.; Sakaguchi, S.; Nagatomo, A.; Kojima, H.; Toyota, M., Heterocycles, 88 (2), 1581-1585 (2014).

5. Takeda, S.; Ogata, Y.; Kojima, H.; Okada, A.; Uranishi, Y.; Nakamura, K., Plant Biotechnol., 28 (1), 77-82 (2011).
6. Kagawa, N.; Sasaki, Y.; Kojima, H.; Toyota, M., Tetrahedron Lett., 51 (3), 482-484 (2010).
7. Kojima, H.; Okada, A.; Takeda, S.; Nakamura, K., Tetrahedron Lett., 50 (50), 7079-7081 (2009).




◎学会発表

[2000 -]
106. Yamamoto, Y.; Kojima, H., "Lipase-catalyzed Allyloxycarbonylation of Alcohols Using Allyl Phenyl Carbonate", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
105. Shimamoto, R.; Machi, Y.; Kojima, H.; Takeda, S., "Asymmetric Reduction of Ketones Using Pisum sativum Seedlings as Whole Cell Biocatalysts", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
104. Otaka, R.; Kojima, H., "Tannase-catalyzed Galloylation of Alcohols in the Mixed Solvent System of Hexane/tert-Butanol", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
103. Nagamoto, T.; Yamamoto, Y.; Kojima, H., "Lipase-catalyzed Benzyloxycarbonylation of Alcohols in the Deep Eutectic Solvent System of Choline Chloride/Urea", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
102. Machi, Y.; Kojima, H.; Takeda, S., "Asymmetric Reduction of Ketones Using Aquatic Plants as Whole Cell Biocatalyst", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
101. Fukui, S.; Kojima, H.; Takeda, S.; Yamanaka, R., "Additive Effects on Asymmetric Reduction of Ketones Using Cyanobacterium Synechocystis sp. PCC 6803", the 23rd Japanese Symposium on the Chemistry of Biocatalysis (2023).
100. 山本悠人、畑山友希、小島秀夫、"炭酸ベンジルフェニルを用いるリパーゼ触媒ベンジルオキシカルボニル化"、第1回学際化学若手育成シンポジウム (2023).
99. Yamamoto, Y.; Hatayama, Y.; Kojima, H., "Lipase-catalyzed Benzyloxycarbonylation of Alcohols", the 103rd CSJ Annual Meeting (2023).
98. Otaka, R.; Hatayama, Y.; Kojima, H., "Galloylation of Alcohols Using Immobilized Aspergillus oryzae Tannase in Organic Media", the 103rd CSJ Annual Meeting (2023).
97. Fukui, S.; Yoshida, J; Kojima, H.; Takeda, S.; Yamanaka, R., "Effect of Additive Concentration on Asymmetric Reduction of Fluorine-containing Ketones Using Cyanobacterium Synechocystis sp. PCC 6803", the 103rd CSJ Annual Meeting (2023).
96. Yoshida, J.; Saito, M.; Kojima, H., "Asymmetric Reduction of Ketones Using Aquatic Plants as Whole-cell Biocatalysts", Active Enzyme Molecule 2022 (2022).
95. Hatayama, Y.; Yamamoto, Y.; Kojima, H., "Lipase-catalyzed Alkoxycarbonylation of Alcohols Using Alkyl Aryl Carbonates", Active Enzyme Molecule 2022 (2022).
94.Otaka, R.; Hatayama, Y.; Kojima, H., "Tannase-catalyzed Galloylation of Alcohols in Organic Solvents", Active Enzyme Molecule 2022 (2022).
93. Fukui, S.; Makigawa, I.; Yoshida, J.; Kojima, H.; Takeda, S.; Yamanaka, R., "Asymmetric Reduction of Fluorine-containing Ketones Using Cyanobacterium Synechocystis sp. PCC 6803", Active Enzyme Molecule 2022 (2022).
92. Azuma, K.; Kojima, H., "Reduction of α-Keto Esters Using Pisum sativum Sprouts", the 102nd CSJ Annual Meeting (2022).
91. Otaka, R.; Hatayama, Y.; Kojima, H., "Immobilized Agents of Tannase Effective for Galloylation of Alcohols", the 102nd CSJ Annual Meeting (2022).
90. Hatayama, Y.; Yamamoto, Y.; Kojima, H., "Lipase-catalyzed Alkoxycarbonylation of Alcohols", the 102nd CSJ Annual Meeting (2022).
89. Yoshida, J.; Saito, M.; Kojima, H., "Asymmetric Reduction of Ketones Using Aquatic Plant Cabomba caroliniana", the 102nd CSJ Annual Meeting (2022).
88. Makigawa, I.; Fukui, S.; Kojima, H.; Takeda, S.; Yamanaka, R., "Control of the Enantioselectivity on Asymmetric Reduction of Fluorine-containing Ketones Using Cyanobacterium Synechocystis sp. PCC 6803", the 102nd CSJ Annual Meeting (2022).
87. Yoshida, J.; Tsuji, T.; Kojima, H., "Asymmetric Reduction of Ketones Using Cabomba Caroliniana", the 101st CSJ Annual Meeting (2021).
86. Hatayama, Y.; Kishi, N.; Kojima, H., "Tannase-Catalyzed Galloylation of Diols", the 101st CSJ Annual Meeting (2021).
85. Kishi, N.; Kojima, H., "Lipase-Catalyzed tert-Butoxycarbonylation of Alcohols", the 101st CSJ Annual Meeting (2021).
84 Azuma, K.; Kojima, H., "Asymmetric Reduction of Ketones Using Pisum Sativum Sprout", the 101st CSJ Annual Meeting (2021).
83. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T.; Nakamura, K., "Effect of Organic Solvents on Asymmetric Reduction of β-Keto Esters Using Cyanobacterium Synechocystis sp. PCC 6803", the 22nd Japanese Symposium on the Chemistry of Biocatalysis (2020).
82. Kishi, N.; Kojima, H., "Lipase Catalyzed tert-Butoxycarbonylation of Diols", the 100th CSJ Annual Meeting (2020).
81. Azuma, K.; Kishi, N.; Kojima, H., "Lipase Catalyzed Silylation of Alcohols", the 100th CSJ Annual Meeting (2020).
80. Tsuji, T.; Yoshida, J.; Kojima, H., "Asymmetric Reduction of Ketones Using Submerged Aquatic Plants of the Family Potamogetonance", the 100th CSJ Annual Meeting (2020).
79. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T., "Asymmetric Reduction of Benzoylformic Acid Esters Using Cyanobacterium Synechocystis sp. PCC 6803", the 100th CSJ Annual Meeting (2020).
78. Kishi, N.; Kojima, H.; Shoji, Y.; Nakanishi, I., "Synthesis and Evaluation of Radical Scavenging Activity of Gallotannins Containing a Quinic Acid Moiety", the 100th CSJ Annual Meeting (2020).
77. Kishi, N.; Kojima, H.; Nakanishi, I., "Synthesis and Evaluation of Radical Scavenging Activity of Gallotannins", the 21st Japanese Symposium on the Chemistry of Biocatalysis (2019).
76. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T.; Nakamura, K., "Asymmetric Reduction of Ketones Using Cyanobacterium Symechosystis sp. PCC6803", the 21st Japanese Symposium on the Chemistry of Biocatalysis (2019).
75. Tsuji, T.; Kojima, H.; Takeda, S., "Biotransformation Using Arabidopsis thaliana", the 21st Japanese Symposium on the Chemistryy of Biocatalysis (2019).
74. Kishi, N.; Kojima, H., "Lipase-Catalyzed tert-Butoxycarbonylation of Alcohols", the 99th CSJ Annual Meeting (2019).
73. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T.; Nakamura, K., "Effect of Light on Asymmetric Reduction of Ketones Using Cyanobacterium Synechocystis sp. PCC6803", the 99th CSJ Annual Meeting (2019).
72. Tsuji, T.; Azuma, K.; Kojima, H., "Biotransformation Using Aquatic Plants", the 99th CSJ Annual Meeting (2019).
71. Kishi, N.; Kojima, H., "Lipase-Catalyzed tert-Butoxycarbonylation Using Boc
2O", the 20th Japanese Symposium on the Chemistry of Biocatalysis (2018).
70. Tanaka, S.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T.; Nakamura, K., "Effect of Light on the Asymmetric Reduction of Ketones Using Cyanobacteria", the 20th Japanese Symposium on the Chemistry of Biocatalysis (2018).
69. Tsuji, T.; Kojima, H.; Takeda, S., "Synthesis of Shikimic Acid Derivatives Using Arabidopsis thaliana", the 20th Japanese Symposium on the Chemistry of Biocatalysis (2018).
68. Kojima, H.; Inui, A.; Takeda, S., "Synthesis of Shikimic Acid Using Arabidopsis thaliana Seedling as a Biocatalyst", the 98th CSJ Annual Meeting (2018).
67. Okubo, F.; Yoshihara, S.; Kojima, H., "シロイヌナズナ植物細胞を用いるケトンの不斉還元", the 19th Japanese Symposium on the Chemistry of Biocatalysis (2017).
66. Nakamura, U.; Tanaka, S.; Katsuhara, T.; Kojima, H.; Takeda, S.; Yamanaka, R.; Takemura, T.; Nakamura, K., "シアノバクテリアSynechosystis sp. 6803を用いるケトンの不斉還元", the 19th Japanese Symposium on the Chemistry of Biocatalysis (2017).
65. Morizane, M.; Sekine (Suzuki), E; Ueno, E.; Nakanishi, I.; Kojima, H., "3,4-ジガロイル-1,6-キノラクトン及び関連化合物の合成と膵リパーゼ阻害活性の評価", the 19th Japanese Symposium on the Chemistry of Biocatalysis (2017).
64. Morizane, M.; Kitagawa, K.; Nishida, K.; Kojima, H., "Pancreatic Lipase Inhibitory Activity of Qunic Acid Derivatives", the 97th CSJ Annual Meeting (2017).
63. Sugimoto, M.; Kojima, H., "リパーゼ触媒不斉アシル化に利用可能な固定化アシルドナーの合成", the 18th Japanese Symposium on the Chemistry of Biocatalysis (2016).
62. Okubo, F.; Maeda, S.; Kojima, H., "Hemianthus callitrichoidesを用いたケトンの不斉還元における蛍光フィルムの効果", the 18th Japanese Symposium on the Chemistry of Biocatalysis (2016).
61. Morizane, M.; Kojima, H., "膵リパーゼ阻害活性を有するキノラクトン類の合成", the 18th Japanese Symposium on the Chemistry of Biocatalysis (2016).
60. Katsuhara, T.; Okubo, F.; Kojima, H.; Takeda, S.; Yamanaka, R.; Nakamura, K., "シアノバクテリアを用いたケトンの不斉還元", the 18th Japanese Symposium on the Chemistry of Biocatalysis (2016).
59. Saga, A.; Inui, A.; Okubo, F.; Takeda, S.; Kojima, H., "シロイヌナズナを生体触媒として用いるシキミ酸誘導体の合成", the 18th Japanese Symposium on the Chemistry of Biocatalysis (2016).
58. Nishida, K.; Kojima, H., "Synthesis of Qunic Acid Derivatives with Pancreatic Lipase Inhibitory Activity", the 96th CSJ Annual Meeting (2016).

57. Sugimoto, M; Sato, M.; Kojima, H., "Lipase Catalyzed Acylation Using Solid Acyl Donors", the 96th CSJ Annual Meeting (2016).
56. Okubo, F.; Kojima, H., "Preparation of Optically Active Alcohols Using Submerged Aquatic Plants as Biocatalysts", the 96th CSJ Annual Meeting (2016).
55. Morizane, M.; Kojima, H., "Enzymatic Galloylation of Alcohols Using Immobilized Tannase", the 96th CSJ Annual Meeting (2016).
54. Okubo, F.; Ujigawa, K.; Kojima, H., "Asymmetric Reduction of Ketones with Aquatic Plants", the 95th CSJ Annual Meeting (2015).
53. Morizane, M.; Nishida, K.; Kojima, H., "Asymmetric Hydrolysis of Gallate Esters with Immobilized Tannase", the 95th CSJ Annual Meeting (2015).
52. Sugimoto, M.; Sato, M.; Kojima, H., "Dynamic Kinetic Resolution of α-Hydroxy Esters by Lipase", the 95th CSJ Annual Meeting (2015).
51. Ujigawa, K.; Ono, M.; Otani, Y.; Kojima, H., "Biotransformation Using Submerged Aquatic Plants", the 94th CSJ Annual Meeting (2014).
50. Nishida, K.; Ihaya, K.; Ujigawa, K.; Kojima, H., "Synthesis of Gallotannins with Pancreatic Lipase Inhibitory Activity", the 94th CSJ Annual Meeting (2014).
49. Ujigawa, K.; Ohtani, Y.; Kojima, H.; Takeda, S.; Yamanaka, R.; Nakamura, K., "Asymmetric Reduction of Fluorine-containing Ketones Using Synechocystis sp. PCC 6803", Active Enzyme Molecule 2014 (2014).
48. Nishida, K.; Sekine-Suzuki, E.; Nakanishi, I.; Ueno, M.; Matsumoto, K.; Murakami, K.; Kojima, H., "Radioprotective Activity of Gallotannins for Rat Tymocytes", the 67th Annual Meeting of Society for Free Radical Research JAPAN (2014).
47. Ujigawa, K.; Ono, M.; Kojima, H., "Asymmetric Reduction of Ketones Using Submerged Aquatic Plants as a Biocatalyst", the 93rd CSJ Annual Meeting (2013).
46. Ihaya, K.; Nishida, K.; Nakanishi, I.; Kojima, H., "Synthesis of Gallotannins and Their Radical-Scavenging Activity", the 93rd CSJ Annual Meeting (2013).
45. Ihaya, K.; Nakanishi, I.; Okubo, K.; Fukuzumi, S.; Kojima, H., "Synthesis of Gallotannins and the Structure-Activity Relationship in Free Radical-Scavenging Reaction", the 66th Annual Meeting of Society for Free Radical Research JAPAN (2013).
44. Ihaya, K.; Nishida, K.; Kojima, H., "Synthesis of Theogallins and Evaluation of Pancreatic Lipase Inhibitory Activity", the 17th, Japanese Symposium on the Chemistry of Biocatalysis (2013).
43. Ujigawa, K.; Kojima, H.; Wada, Y.; Takeda, S.; Nakamura, K., "シロイヌナズナの酸化還元酵素遺伝子破壊株を用いたケトンの不斉還元", the 17th Japanese Symposium on the Chemistry of Biocatalysis (2013).
42. Ono, M.; Ujigawa, K.; Kojima, H., "カヤツリグサ科の水生植物を用いたケトンの不斉還元", the 17th Japanese Symposium on the Chemistry of Biocatalysis (2013).
41. Ihaya, K.; Usa, R.; Kojima, H., "Synthesis of Theogallin Derivatives with Pancreatic Lipase Inhibitory Activity", the 92nd CSJ Annual Meeting (2012).
40. Matsumoto, Y.; Sato, M.; Kojima, H., "Dynamic Kinetic Resolution by Lipases in Flow Systems", the 92nd CSJ Annual Meeting (2012).
39. Matsumoto, Y.; Sato, M.; Kojima, H., "Dynamic Kinetic Resolution of Alcohols Using Immobilized Lipases and Acid Resin Catalysts in a Continuous Flow System", the 16th Japanese Symposium on the Chemistry of Biocatalysis (2012).
38. Ujigawa, K.; Kojima, H.; Wada, Y.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones Using Arabidopsis thaliana Mutant as a Biocatalyst", the 16th Japanese Symposium on the Chemistry of Biocatalysis (2012).
37. Usa, R.; Ihaya, K.; Kojima, H., "Chemoenzymatic Synthesis of Glucosyl Esters of Aromatic Hydroxy Acids", the 91st CSJ Annual Meeting (2011).
36. Uranishi, Y.; Sato, M.; Kojima, H., "Dynamic Kinetic Resolution of Alcohols by Immobilized Lipases in Flow Systems", the 91st CSJ Annual Meeting (2011).
35. Usa, R.; Ihaya, K.; Kojima, H., "Synthesis of Glucosyl Esters of Aromatic Hydroxy Acids", the 15th Japanese Symposium on the Chemistry of Biocatalysis (2011).
34. Matsumoto, Y.; Uranishi, Y.; Sato, M.; Kojima, H., "フロー系におけるリパーゼを用いたアルコールの動的速度論的光学分割", the 15th Japanese Symposium on the Chemistry of Biocatalysis (2011).
33. Usa, R.; Kojima, H., "Synthesis of Synapoyl Glucoside Using Lipase", the 90th CSJ Annual Meeting (2010).
32. Usa, R.; Kojima, H., "Chemo-enzymatic Synthesis of 1-O-Hydroxycinnamoyl-β-D-glucoses", the14th Japanese Symposium on the Chemistry of Biocatalysis (2010).
31 Takeda, S.; Ogata, Y.; Kojima, H.; Okada, A., "Arabidopsis Thaliana as a Novel Useful Biocatalyst for Asymmetric Reductions", the 51st Annual Meeting of the Japanese Society of Plant Physiology (2010).
30. Kojima, H.; Usa, R.; Nakamura, K., " Synthesis of Glucosyl Esters of Hydroxycinnamic Acids Using Lipase", the 13th Japanese Symposiun on the Chemistry of Biocatalysis (2009).
29. Kojima, H.; Saeki, M.; Nakamura, K., "Synthesis of Monoglucosaminyl Diglycerides Using Lipase", the 88th CSJ Annual Meeting (2008).
28. Okada, A.; Kojima, H.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones by Cultured Cells of Nicotiana tabacum", the 88th CSJ Annual Meeting (2008).
27. Okada, A.; Kojima, H.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones by Cultured Cells of Nicotiana tabacum", the 12th Japanese Symposium on the Chemistry of Biocatalysis (2008).
26 Sasaki, Y.; Kagawa, N.; Kojima, H.; Toyota, M., "Novel Catalytic Olefination Using Lanthanoid Metals", the 33rd Symposium on Progress in Organic Reactions and Syntheses (2007).
25. Okada, A.; Kojima, H.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones by Cultured Cells of Nicotiana tabacum", the 87th CSJ Annual Meeting (2007).
24. Kimoto, R.; Kojima, H.; Nakamura, K., "Synthesis of Coixenolide from Adlay Seed", the 87th CSJ Annual Meeting (2007).
23. Okada, A.; Kojima, H.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones by Cultured Cells of Nicotiana tabacum", the 11th Japanese Symposium on the Chemistry of Biocatalysis (2007).
22. Kojima, H.; Okamoto, A.; Kimoto, R.; Nakamura, K., " Synthesis of Optically active Esters of meso-2,3-Butanediol Using Lipase", the 11th Japanese Symposium on the Chemistry of Biocatalysis (2007).
21. Kojima, H.; Saeki, M.; Nakamura, K., "Synthesis of Monoglucosaminyl Diglycerides Using Lipase", the 11th Japanese Symposium on the Chemistry of Biocatalysis (2007).
20. Kojima, H.; Yamaguchi, M.; Omori, A.; Nakamura, K., "Lipase-catalyzed Selective Hydrolysis of Acetic Esters", the 11th Japanese Symposium on the Chemistry of Biocatalysis (2007).
19. Kojima, H.; Yamamoto, Y.; Nakamura, K., " Lipase-catalyzed Reactions Using 1-Ethoxycyclopropyl Esters as Acyl Donors", the 86th CSJ Annual Meeting (2006).
18. Omori, A.; Kojima, H.; Nakamura, K., "Synthesis of Natural Products by Enzymatic Glucosylation", the 10th Japanese Symposium on the Chemistry of Biocatalysis (2006).
17. Okada, A.; Kojima, H.; Takeda, S.; Nakamura, K., "Asymmetric Reduction of Ketones by Cultured Cells of Arabidopsis thaliana", the 10th Japanese Symposium on the Chemistry of Biocatalysis (2006).
16. Kimoto; R.; Kojima, H.; Nakamura, K., "Lipase-catalyzed Monoacylation of Diols", the 10th Japanese Symposium on the Chemistry of Biocatalysis (2006).
15. Okamoto, K.; Omori, A.; Kojima, H., "Secondary Amine-catalyzed Asymmetric Diels-Alder Reaction in Chiral Ionic Liquides", the 85th CSJ Annual Meeting (2005).
14. Omori, A.; Okamoto, K.; Kojima, H., "Lantanoid Triflate-catalyzed Aldol Reaction in Amphiphilic Ionic Liquid-Water System", the 85th CSJ Annual Meeting (2005).
13. Sawano, C.; Oshima, R.; Kojima, H., "Synthesis of Highly Strained 1-Ethoxycyclopropyl Acetate and its Application to Lipase-catalyzed Enantioselective Acylation", the 85th CSJ Annual Meeting (2005).
12. Kojima, H.; Sawano, C.; Nakamura, K., "Synthesis of Highly Strained Cyclopropyl Esters and their Application to Lipase-catalyzed Enantioselective Acylation", International Chemical Congress of Pacific Basin Societies (2005).
11. Okamoto, K.; Kojima, H., "Preparation of Lanthanoid Complexes Bearing Amphiphilic Chiral Ligands Derived from Sugars", the 84th CSJ Annual Meeting (2004).
10. Kuratoko, H.; Kojima, H., "Synthesis of Chiral Ionic Liquids Derived from Optically Active Sulfonic Acids", the 84th CSJ Annual Meeting (2004).
9. Sawano, C.; Kojima, H., The Baker's Yeast Reduction of Keto Esters in the Presence of Thioglycosides", the 84th CSJ Annual Meeting (2004).
8. Sawano, C.; Kojima, H., The Baker's Yeast Reduction of β-Keto Esters in the Presence of Thioglycosides", the 8th Japanese Symposium on the Chemistry of Biocatalysis (2004).
7. Yamamoto, S.; Kojima, H., "Synthesis of Oligosaccharides by Sequential Glycosylation Using Thiocellobiosides", the 83rd CSJ Annual Meeting (2003).
6. Fukuma, E.; Kojima, H.; Tsukamoto, T., "Molecular Dynamics Simulation of Aqueous Solution of Trehalose Derivatives with Alkyl Chains", the 83rd CSJ Annual Meeting (2003).
5. Yamamoto, S.; Kojima, H., "Synthesis of Oligosaccharides Using Thiocellobiosides", the 82nd CSJ Annual Meeting (2002).
4. Kojima, H.; Ikemoto, M.; Ueno, E.; Kojima, M., "Synthesis of Thiol-Bearing Trehalose-Based Surfactants", the 81st CSJ Annual Meeting (2002).
3. Kojima, H.; Nishio, S.; Hanai, S.; Yokoji, M., "Synthesis of Thiol-Bearing Glucose-Based Surfactants", the 79th CSJ Annual Meeting (2001).
2. Kojima, H.; Kimura, S.; Tanaka, N.; Nagano, H., "Synthesis of Sulfur-Containing Trehalose Lipids", the 78th CSJ Annual Meeting (2000).
1. Kojima, H.; Nishio, S.; Hanai, S.; Yokoji, M., "Preparation of Sulfer-containing Trehaloselipids", International Chemical Congress of Pacific Basin Societies (2000).